In short: MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene, supplied by Vexar Lab strictly for in-vitro laboratory research and not approved for human consumption. It is a widely studied tool compound in metabolic and mitochondrial-signalling research. Before ordering any peptide, research buyers should confirm purity of at least 99% by HPLC, identity confirmation by mass spectrometry, and clear batch numbering with a corresponding certificate of analysis (COA).
What is MOTS-c?
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a short peptide notable for being encoded by mitochondrial DNA rather than the nuclear genome — one of the first peptides discovered to be produced this way. This finding helped establish that mitochondria actively signal to the rest of the cell through dedicated peptides. In research it is described as a regulator of cellular metabolism that circulates in the bloodstream and acts on metabolic tissues, making it a frequently used reference compound in studies of mitochondrial-to-nuclear communication.
What does the research investigate?
Pre-clinical literature has examined MOTS-c chiefly for its reported activation of the AMPK pathway, effects on glucose uptake in skeletal muscle, and modulation of the folate-methionine cycle. Because circulating levels are reported to rise with exercise in some studies, it is often referred to in the literature as an “exercise mimetic.” Animal research has explored its role in diet-induced metabolic dysfunction, insulin sensitivity, and age-related metabolic changes. These are investigational findings from cell and animal models and do not establish safety or efficacy for any human use. Always read the primary sources directly.
Purity and quality: what research buyers should check
- Purity of at least 99% by HPLC — confirm the figure against the batch-specific COA rather than a generic specification sheet.
- Identity confirmation by mass spectrometry — the measured mass should match the expected molecular weight of the peptide.
- Batch numbering — every vial should trace back to a documented production batch and its analytical records.
Vexar Lab supplies MOTS-c as a pack of 10 vials, ≥99% HPLC-verified, batch-numbered, with mass-spec confirmation.
Handling and storage
MOTS-c is supplied lyophilised. Standard laboratory practice for lyophilised peptides applies: store the sealed vials cold and protected from light, reconstitute only with an appropriate sterile solvent immediately before use, and aliquot to avoid repeated freeze-thaw cycles. Reconstituted peptide is generally less stable than the dry powder and should be kept refrigerated and used within a short working window. Follow your own institution’s handling protocols.
Wholesale supply
Vexar Lab supplies MOTS-c to research buyers and resellers in packs of 10 vials, with a £300 minimum order, bulk pricing on volume, £45 flat worldwide shipping, and optional custom labelling for resellers.
Frequently asked questions
Is MOTS-c approved for human use?
No. Vexar Lab supplies MOTS-c strictly as a research material for in-vitro laboratory use. It is not sold for human consumption, and nothing here constitutes medical or dosing guidance.
What purity does Vexar Lab guarantee?
Each batch is verified at ≥99% by HPLC with identity confirmed by mass spectrometry, and every vial is batch-numbered against its COA.
How is it shipped and packaged?
It ships lyophilised in packs of 10 vials, with £45 flat worldwide shipping and batch documentation available on request.
This guide is provided for research-only purposes. MOTS-c is supplied strictly for in-vitro laboratory research and is not approved for human consumption. No medical, therapeutic, or dosing advice is given or implied.
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