In short: MGF (Mechano Growth Factor, IGF-1Ec) is a splice variant of the IGF-1 gene studied in pre-clinical models for local muscle-repair signalling. It is supplied strictly for in-vitro laboratory research and is not approved for human consumption. Research buyers should confirm any material against three criteria before purchase: ≥99% purity by HPLC, identity confirmed by mass spectrometry, and clear batch numbering tied to a certificate of analysis.
What is MGF?
Mechano Growth Factor (MGF) is a splice variant of the IGF-1 gene — IGF-1Ec in humans, IGF-1Eb in rodents — that is transiently expressed in skeletal muscle, heart and bone in response to mechanical loading or tissue damage. It shares the mature IGF-1 sequence but carries a unique C-terminal E-peptide that research suggests has independent biological activity. It is handled in the laboratory as a lyophilised powder reconstituted for in-vitro work; a PEGylated form (PEG-MGF) is also used in research to extend stability.
What does the research investigate?
Pre-clinical and in-vitro research into MGF has focused on activation of muscle satellite (stem) cells, proliferation and differentiation signalling, and markers of muscle regeneration in rodent injury models. Studies of PEG-MGF report changes in satellite-cell number and myofiber cross-sectional area relative to controls. The absence of controlled human trials means these are investigational findings that do not establish human safety or efficacy. Always read the primary sources directly.
Purity and quality: what research buyers should check
- ≥99% purity by HPLC — confirm via the batch certificate of analysis (COA).
- Identity confirmed by mass spectrometry against the expected peptide mass.
- Batch numbering that ties each vial to its COA for traceability.
Vexar Lab supplies MGF as a pack of 10 vials, ≥99% HPLC-verified, batch-numbered, with mass-spec confirmation.
Handling and storage
Standard lyophilised-peptide practice applies. Store sealed vials of lyophilised powder at -20°C, away from light and moisture. After reconstitution with a suitable solvent, refrigerate and use within a short working window, avoiding repeated freeze-thaw cycles that can degrade peptide integrity. Allow vials to reach room temperature before opening to limit condensation.
Wholesale supply
Vexar Lab supplies research peptides in packs of 10 vials, £300 minimum order, with bulk pricing on volume, £45 flat worldwide shipping, and optional custom labelling for resellers.
Frequently asked questions
Is MGF approved for human use?
No. MGF is supplied strictly for in-vitro laboratory research and is not approved for human consumption or any therapeutic use.
How does MGF relate to IGF-1?
MGF is a splice variant of the IGF-1 gene with a distinct C-terminal E-peptide; its locally-acting role is studied in pre-clinical models only.
How should purity be verified?
Request the batch certificate of analysis showing ≥99% purity by HPLC and a mass-spectrometry identity confirmation tied to the vial’s batch number.
This guide is provided for informational purposes only. MGF is sold strictly as a research-only chemical for in-vitro laboratory use and is not for human or veterinary consumption, diagnosis, or treatment.
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